The Apoe−/− mouse model: a suitable model to study …
WEBMay 20, 2016 · The Apoe −/− mouse was developed in 1992 by homologous recombination of embryonic stem cells, and it is currently the most widely used pre-clinical model of atherosclerosis [9, 26]. Apoe is a ligand for lipoprotein receptors involved in lipoprotein recognition and clearance.
The Apoe−/− mouse model: a suitable model to study …
WEBMay 20, 2016 · Atherosclerosis-prone apolipoprotein E-deficient (Apoe −/−) mice display poor lipoprotein clearance with subsequent accumulation of cholesterol ester-enriched particles in the blood, which promote the development of atherosclerotic plaques.
002052 - ApoE KO Strain Details - The Jackson Laboratory
WEBCommon Name: ApoE KO. Mice homozygous for the Apoetm1Unc knock-out mutation show a marked increase in total plasma cholesterol levels that are unaffected by age or sex. Fatty streaks in the proximal aorta are found at three months of age.
ApoE knockout and knockin mice: the history of their ... - PubMed
WEBApoe-deficient mice and human apoE isoform knockin mice, as well as hypomorphic Apoe mice, have significantly contributed to our understanding of the role of apoE in lipoprotein metabolism, monocyte/macrophage biology, and atherosclerosis.
Comprehensive Introduction of Apoe Knockout Mice - Cyagen
WEBJul 2, 2021 · Apoe knockout mice are widely used to study the function of APOE in atherosclerosis, lipid metabolism, and nerve damage. These mice also help to study interventional therapies that can change the atherosclerotic process.
ApoE | Taconic Biosciences
WEBHomozygous ApoE mice are devoid of apoE protein. Mice develop normally, but exhibit five times normal serum plasma cholesterol and spontaneous atherosclerotic lesions. Studies indicate a role for ApoE in immune system regulation, nerve regeneration, and muscle differentiation.
Atherosclerosis in the Apolipoprotein E–Deficient Mouse:
WEBApr 15, 2004 · The apolipoprotein E–deficient (apoE−/−) mouse is currently the most popular murine model used for atherosclerotic studies. This review outlines the uses and limitations of, and plaque pathology in...
ApoE knockout and knockin mice: the history of their contribution …
WEBFeb 14, 2016 · Apoe-deficient mice and human apoE isoform knockin mice, as well as hypomorphic Apoe mice, have significantly contributed to our understanding of the role of apoE in lipoprotein metabolism, monocyte/macrophage biology, and atherosclerosis.
APOE4 accelerates advanced-stage vascular and ... - Nature
WEBJun 14, 2021 · Using aged APOE knock-in mice crossed with 5xFAD mice, we show that, compared to APOE3, APOE4 accelerates blood–brain barrier (BBB) breakdown, loss of cerebral blood flow, neuronal loss and ...
Alzheimer's disease pathology in APOE transgenic mouse …
WEBJun 1, 2020 · Because the heterologous promoter strategy results in overexpression of apoE significantly above normal protein levels, these mice have not received widespread use. Instead, APOE-TR mice, which express h-apoE at normal physiological levels, are more prevalent given their greater accuracy and translatability. However, models of neuron- …
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