An operant social self-administration and choice model in mice
WEBMar 24, 2023 · Here we describe how to use our operant social learning and choice model in mice, providing a standardized protocol of operant social interaction self-administration, social seeking during...
An Improved Model of Physical and Emotional Social Defeat: …
WEBDec 11, 2018 · The present study attempted to establish an improved social stress model to better distinguish the effects of physical and emotional social stress on the behavior and physiology of adolescent mice. In addition, we investigated how social support affected these stress-induced changes in social behavior.
Distinct dynamics of social motivation drive differential social ...
WEBNov 20, 2020 · Laboratory rat and mouse strains serve as animal models to explore brain mechanisms underlying social behavior. Here, the authors describe differences in social behavior between commonly...
Social support rescues acute stress-induced cognitive impairments …
WEBAug 13, 2018 · Our results suggest that social support can alleviate the RS-induced cognitive impairments partly by modulating ERK1/2 phosphorylation and gene transcription in the PFC, and provide novel insights into the molecular mechanisms of the stress-buffering effects of social support.
Social support rescues acute stress-induced cognitive ... - Nature
WEBAug 13, 2018 · Here, we employed a pro-social behaviour paradigm and a restraint stress model to evaluate the effects of social support on acute stress at the cellular and behavioural levels 30,35.
Making “Good” Choices: Social Isolation in Mice Exacerbates the …
WEBMay 25, 2020 · Here we used a mouse model to investigate the changes in decision-making caused by the experience of chronic stress and the role of social isolation in exaggerating these changes.
Waving Through the Window: A Model of Volitional Social …
WEBJun 1, 2022 · Mouse models of social behavior fail to account for volitional aspects of social interaction, and current neurobiological investigation of social behavior is performed almost exclusively using C57BL/6J mice, the background strain of most transgenic mice.
Waving Through the Window: A Model of Volitional Social
WEBJun 1, 2022 · Our data show that CD1 mice are a better strain for studying female social reward learning. Our mouse operant social model provides a tool for research on neurobiological substrates of female social reward and disruption of social reward in psychiatric disorders using mouse-specific genetic tools.
An operant social self-administration and choice model in mice
WEBUsing mice, we systematically compared female adolescent and adult C57BL/6 mice and outbred CD1 mice, showing that operant social self-administration, social seeking during periods of isolation and choice of social interaction over palatable food is significantly stronger in female CD1 mice than in female C57BL/6J mice, independently of age.
An operant social self-administration and choice model in mice
WEBThe use of mice allows one to probe the neurobiological bases of social interaction, offering the genetic diversity and versatility to identify cell. … more. Figures (0) & Videos (0) Fig. 1 : Social-choice self-administration apparatus. Fig. 2 : Protocol timeline.
Skip to content