Marles-les-Mines is a commune in the Pas-de-Calais department in the Hauts-de-France region of France about 5 miles southwest of Béthun…Marles-les-Mines is a commune in the Pas-de-Calais department in the Hauts-de-France region of France about 5 miles southwest of Béthune and 36 miles southwest of Lille. The river Clarence flows through the commune. Vis-à-Marles station is the local train station.