Picinisco is a comune in the Province of Frosinone in the Italian region Lazio, located about 120 kilometres east of Rome and about 45 kilom…Picinisco is a comune in the Province of Frosinone in the Italian region Lazio, located about 120 kilometres east of Rome and about 45 kilometres east of Frosinone. It is included in the Valle di Comino and National Park of Abruzzo, Lazio e Molise.