San Juan de Guadalupe is a municipality in the Mexican state of Durango. The municipal seat lies at San Juan de Guadalupe. The municipality …San Juan de Guadalupe is a municipality in the Mexican state of Durango. The municipal seat lies at San Juan de Guadalupe. The municipality covers an area of 2343.1 km². As of 2010, the municipality had a total population of 5,947, up from 5,858 as of 2005.