Demi Moore, whose movie credits date back to the start of the 1980s, has won virtually nothing of note in all those years. Her nomination for The Substance, a satiric body-horror movie in which she plays an aging star undone by what’s supposed to be a revitalizing serum,

Mikey Madison won the best actress Oscar on Sunday for “Anora," a role that catapulted the 25-year-old into a film career after achieving initial success on television. Her victory was part of a huge night for the Brooklyn-set comedy-drama,

Moore had been considered a favorite for her strong performance in “The Substance,” but Madison won for “Anora.”