About Tigulixostat (LC350189, IBI350) Tigulixostat is a novel xanthine oxidase inhibitor targeting the reduction of uric acid in purine metabolism, by inhibiting the activity of xanthine oxidase.

By analyzing the blood and cerebrospinal fluid (CSF) of the patients, researchers have discovered critical impairments in purine metabolism and the recycling of adenosine triphosphate (ATP)-;the ...

so called de novo purine synthesis, rather than from recycling, which is the body's other option. That's the same high energy purine producing process they found vascular smooth muscle cells on ...

So far as is known today, uric acid serves no biochemical function in the body other than being an end product of purine metabolism. The metabolically important purines, adenine and guanine ...

Xanthine oxidase is an essential enzyme within the uric acid metabolic pathway and is required for the breakdown of purine nucleotides ... need for xanthine oxidase inhibition to treat those ...