Located on a 27-acre islet, this hotel is reached via 24-hour ferry leaving from the dock at Opal Key Resort and Marina. This is Key West's best-kept secret, even if it isn't on Key West.

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Named for Mile Marker 0 (the famous photo op that marks the end of U.S. Highway 1), The Marker Key West Harbor Resort is ideally located in a quiet cul-de-sac in Old Town, right along the historic ...