Objective This study aims to evaluate the role of antiphospholipid antibodies (aPLs) in patients with SLE with heart valve ...

Objective The objective of this review is to highlight the role of Neutrophil Extracellular Traps (NETs) in the pathogenesis of Systemic Lupus Erythematosus (SLE), focusing on their development, ...

Background Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by multiple organ involvement. Atherosclerosis is the underlying cause of SLE-related cardiovascular ...

Objective BAFF and APRIL signal through TACI, BCMA, and/or BAFF-R, and play important roles in the activation, differentiation, and/or survival of B cells, particularly antibody-secreting cells, as ...

Purpose TLR7 and TLR8 (TLR7/8) are members of the Toll-Like Receptor family that recognize single strand RNA. Activation of TLR7/8 within immune cells elevates pro-inflammatory cytokines and type ...

Introduction Double-stranded-DNA antibodies (antiDNAds) are the most frequently detected serological markers in patients with Systemic Lupus Erythematosus (SLE). In clinical practice, it is usually ...

Background Pathogenic extrafollicular double negative 2 (DN2) B cells in SLE have a phenotype of IgD − CD27 − Tbet + CD11c +, and are the precursor of ribonuclear protein (RNP) autoantibody producing ...

Objectives This study aimed to investigate hemostatic variables in pregnant patients with Systemic Lupus Erythematosus (SLE) in relation to preeclampsia (PE), antiphospholipid antibody (aPL) status ...

Background Systemic lupus erythematosus (SLE) is a chronic, complex autoimmune disease characterized by pathogenic autoantibodies and tissue damage to multiple organ systems. Nipocalimab is a novel ...

Background/Purpose The long-term morbidity and mortality of childhood-onset SLE (cSLE) after transition to adult care is not well documented. The present study aims to fill this knowledge gap by ...

Background Systemic Lupus Erythematosus (SLE) is a prototypic, systemic autoimmune disease that can affect many organs. Current treatment of SLE is largely empirical, while the existing ...

Objective Renal flares in patients with systemic lupus erythematosus (SLE) result in significant nephron loss. Thus, identification of reliable early signals of impending renal flares is anticipated ...