In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the ...

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein-;the most important genetic risk factor for ...

A team of scientists has found that the presence of the APOE4 protein -- the most important genetic risk factor for Alzheimer ...

The mouse model not only carries human APOE genes, but the team also transplanted human neurons producing the APOE4 protein into the brains of mice. On removing microglia, they discovered that the ...

Reducing microglial activity in the presence of apolipoprotein E4 (APOE4) has uncovered a mechanism associated with the deposition of misfolded amyloid and tau in a novel mouse model of Alzheimer’s ...

Some people have a version of a gene (ApoE) that increases their risk of Alzheimer's disease ... This could contribute to the underlying Alzheimer's disease mechanism. It has been shown in mice that ...

Meanwhile, exogenous CTRP9 inhibited atherosclerotic plaque formation in ApoE KO and CTRP9 KO mice (45). CTRP9 binds to the receptors AdipoR1 and N-cadherin to activate multiple signaling pathways and ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.