Reducing microglial activity in the presence of apolipoprotein E4 (APOE4) has uncovered a mechanism associated with the deposition of misfolded amyloid and tau in a novel mouse model of Alzheimer’s ...
The mouse model not only carries human APOE genes, but the team also transplanted human neurons producing the APOE4 protein into the brains of mice. On removing microglia, they discovered that the ...
In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein-;the most important genetic risk factor for ...
New research shows that microglia, which usually clear debris, cause harmful inflammation in the presence of APOE4 protein.
A team of scientists has found that the presence of the APOE4 protein -- the most important genetic risk factor for Alzheimer ...
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