The products, known as topical anesthetics contain lidocaine, tetracaine, benzocaine and prilocaine in a cream, ointment or gel.

In clinical trials, lidocaine/tetracaine 7%/7% cream was associated with local adverse events, including erythema (47%), skin discoloration (16%), and edema (14%). Most of these events were transient.

Of the 20 patients, 19 (95%) said they had less pain on the cheek that received the new lidocaine-tetracaine mixture ( P < .001). The mean pain score of the study drug was 2.66 compared with 5.25 ...

Adequate pain relief was achieved in 13 percent with lidocaine/tetracaine, compared to 73 percent with lidocaine/prilocaine in Study A (P = 0.004); the corresponding proportions in Study B were 53 ...

Topical anesthetic Pliaglis Cream is now available as a local analgesic for superficial dermatological procedures such as dermal filler injection and pulsed dye laser therapy.

The recall involves "Synodrin Lidocaine Maximum Strength Pain Relieving Cream" sold at Albertsons, Safeway, Rite-Aid, Giant, Harris Teeter, Meijer, Stop &amp; Shop, Jet.com and Amazon.com.

In a study from 2002, researchers found that a 5% lidocaine-prilocaine cream increased the average PE period by 8.7 minutes (+/- 1.7 minutes) when applied before intimacy.