The Detroit Lions are coming off a 15-2 season and an NFC North championship. They start out the 2025 campaign with a target, and that target is in the crosshairs right off the bat in the freshly released Lions schedule.

The official NFL schedule for 2025 is out, and one Detroit Lions game rises above the rest as the most important of the season.

With the NFL schedule officially unveiled, here is Lions OnSI's first game-by-game prediction for the Lions' 2025 season. Week 1 - Sunday, Sept. 7 -- at Packers (4:25 p.m. ET) Prediction: 30-23 win (1-0). Week 2 - Sunday, Sept. 14 -- vs. Bears (1 p.m. ET) Week 3 - Monday, Sept. 22 -- at Ravens (8:15 p.m. ET)