Immunotherapy has revolutionized cancer treatment by mobilizing the immune system to attack tumor cells. Major advances, such as immune checkpoint inhibitors (notably against the PD-1 protein), have ...

Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec H3A 2K6, Canada, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West ...

Find more information on the Altmetric Attention Score and how the score is calculated. Inhibition of multiple enzymes of the arachidonic acid cascade leads to synergistic anti-inflammatory effects.

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

Recent advancements reveal a critical role of lipid metabolism dysregulation in the pathogenesis and severity of depressive disorders. This review elucidates the impact of lipid imbalance on ...

The final, formatted version of the article will be published soon. Objective: This study aimed to investigate the effects of PAItrap3, a novel PAI-1 inhibitor, on lipid metabolism, and autophagy ...