Today's super-resolution microscopes have made it possible to observe the nanoscale world with unprecedented detail. However, ...

The Milestones aim to highlight the most influential developments in light microscopy in a series of short articles, each describing a major achievement. Nature Milestones in Light Microscopy also ...

This includes studying interactions within organoids, organs and even whole organisms. With light sheet microscopy, you can image a sample as large as a whole mouse, in 3D, at cellular resolution ...

This causes the molecules in the sample to move apart evenly and also become larger, so that they can be imaged with a light microscope after being specifically labeled with fluorescent molecules.

You should not look through the microscope to do this. Line it up so that the specimen - if you can see it - is in the centre of the stage, where the light passes through. Focus the slide by ...