The revival effort took shape in Colossal’s Dallas lab, where scientists engineered the dire wolf by modifying the DNA of a close relative — the gray wolf. “We used gray wolf cells ...

These pups, born of a gray wolf’s lineage ... They have taken great care, it is said, to avoid the mistakes of the past, for the dire wolf’s return must not be marred by folly.

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Three dire wolf pups — aptly named Romulus, Remus and Khaleesi — were successfully born using DNA from ancient dire wolf fossils and genes from their closest living relative, the grey wolf.

With further genetic discoveries, Colossal's team took it a step further. They identified 20 distinct genes that defined the dire wolf and edited them into the DNA of grey wolves — their closest ...

Three genetically engineered wolves that may resemble extinct dire wolves are trotting, sleeping and howling in an undisclosed secure location in the U.S., according to the company that aims to ...

This undated photo provided shows two pups that were genetically engineered with similarities to the extinct dire wolf. (Colossal Biosciences Handout via AP Photo) Then the scientists took blood cells ...

A biotech company says it has bred three animals with key physical features of the dire wolf — a species that has been extinct for more than 12,000 years. Colossal Biosciences says it used novel ...

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Then the scientists took blood cells from a living gray wolf and used CRISPR to genetically modify them in 20 different sites, said Colossal's chief scientist Beth Shapiro. They transferred that ...

During the process, Colossal also developed a non-invasive blood cloning method that it used to birth two litters of the highly endangered red wolf. Dire wolves share 99.5% of their DNA with gray ...

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