"Our findings suggest that decreased uric acid levels in patients with PD are influenced by factors beyond purine metabolism, including external factors such as sex, weight, and age," said Dr ...

The study showed, on the one hand, that inhibiting purine supply as well as disturbing purine synthesis can trigger a functional disturbance of BRD4 and thus impact chromatin accessibility.

Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle, ...

Hyperuricemia Uric Acid Metabolism So far as is known today, uric acid serves no biochemical function in the body other than being an end product of purine metabolism. The metabolically important p ...

Neuron-like cells created from a readily available cell line have allowed researchers to investigate how the human brain makes a metabolic building block essential for the survival of all living ...

Gerta Hoxhaj, a cancer metabolism researcher at the Children’s Medical Center Research Institute at the University of Texas Southwestern, led a team of researchers to tackle this challenge.They ...

Purines are a class of organic compounds that play a crucial role in the building blocks of life. They are heterocyclic aromatic compounds consisting of a pyrimidine ring fused to an imidazole ring.

Here, the team tried a similar method of inhibiting purine synthesis. While it worked well in DIPG cells, it was less impressive in animal models. Wahl explains that, ...

The findings were published in Cancer & Metabolism. Wahl's team has previously explored how purines are metabolized in adult glioblastoma, including a clinical trial to see how blocking purine ...

Neuron-like cells created from a readily available cell line have allowed researchers to investigate how the human brain makes a metabolic building block essential for the survival of all living ...