DOI: 10.1021/acs.jpcb.2c08631 ... Louie Slocombe, Max Winokan, Jim Al-Khalili, Marco Sacchi (2022) Proton transfer during DNA strand separation as a source of mutagenic guanine-cytosine tautomers, In: ...

Scientists have known since the discovery of DNA's structure in the 1950s that base pairs can, in theory, produce tautomers. But they thought that quantum tunneling would have little relevance as ...

Mistakes happen.Specifically, a significant part of the mutation process is the displacement of a single hydrogen that glues together the genetic bases to make the 'rungs' of DNA's twisted ladder ...

For now, though, "it's hard to say" what concentration of DNA building blocks meteorites would have needed to contain to help drive the emergence of life on Earth, said Jim Cleaves, a geochemist ...

DOI: 10.1038/s41598-023-48119-z ... Louie Slocombe, Max Winokan, Jim Al-Khalili, Marco Sacchi (2023) Quantum Tunnelling Effects in the Guanine-Thymine Wobble Misincorporation via Tautomerism, In: The ...

Rare tautomers promote the spontaneous mutations and are not detected easily. These mutations are not referred to the random mutations in Watson–Crick (WC) pairs [the genetic code being located in the ...

By contrast, for normal DNA bases (such as cytosine), the keto tautomers are the major ones, whereas enol tautomers are very rare (31, 38, 50). Taken together, the NMR observations demonstrated the ...