The Cleveland Guardians defeated the Baltimore Orioles 6-3 in a competitive Orioles vs Guardians matchup on July 22, 2025, at Progressive Field, as seen in the sports card above. José Ramírez’s first-inning home run set the tone,

Angel Martínez had three hits, José Ramírez homered and the Cleveland Guardians defeated the Baltimore Orioles 6-3 Tuesday night for their fourth win in five games since the All-Star break. Kyle Manzardo and Bryan Rocchio each drove in a pair of runs as the Guardians have won 10 of 12 after a 10-game losing streak to get back to .500 at 50-50.

The Guardians took the second of the four-game series with the Orioles, 6-3, a day after winning the opener, 10-5. Cleveland is on a three-game winning streak, 4-1 in the past five and 8-2 over the last 10, so the Guardians are getting hot, while the O’s are 1-6 in the last seven.

The Guardians used a left-handed starter and stacked nine lefties and/or switch-hitters in their lineup to beat the Orioles on Tuesday.

Preview the July 23 matchup between the Cleveland Guardians and Baltimore Orioles with odds over/under, game spread, betting lines and more.

CLEVELAND — The Guardians face the Baltimore Orioles as Cleveland, for really the first time this season, looks to continue the recent offensive surge. The Guardians are coming off of a 10-5 win on July 21, and they've averaged more than six runs over their last 11 games.

Cleveland has won 8 of 10 but is still 11 games back in the division. Critical decisions face the front office, hinging on the Guards' performance against Baltimore.

Since then, though, Cleveland has been red hot. They’ve won eight of their last 10 games, including a sweep of the Astros and series wins over the White Sox and Athletics, the two worst teams in the American League. Now they’ll get to face the third-worst team, the Orioles, with a chance to keep the good times rolling.