The Cleveland Guardians defeated the Baltimore Orioles 6-3 in a competitive Orioles vs Guardians matchup on July 22, 2025, at Progressive Field, as seen in the sports card above. José Ramírez’s first-inning home run set the tone,

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Angel Martínez had three hits, José Ramírez homered and the Cleveland Guardians defeated the Baltimore Orioles 6-3 Tuesday night for their fourth win in five games since the All-Star break.

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The Baltimore Orioles have had a disappointing season this year and are looking to move expendable assets without jeopardizing their young core and next season.

The Orioles’ first three picks were Auburn catcher/corner outfielder Ike Irish (No. 19), Coastal Carolina catcher Caden Bodine (No. 30) and Wehiwa Aloy (No. 31). The No. 19 pick was the Orioles’ original first-round selection, while Nos. 30 and 31 were compensation for losing Corbin Burnes and Anthony Santander in free agency.

José Ramírez had a three-run homer in the first inning, Brayan Rocchio delivered a two-run single in the seventh and the Cleveland Guardians pulled away for a 10-5 victory over the Baltimore Orioles.

The once-elite Baltimore Orioles farm system had fallen to near the bottom of the league after a flurry of graduations, but a strong 2025 MLB draft has them gai

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