In the early phase of Alzheimer’s disease, astrocytes are the primary source of APOE in the brain. This study examined the ...

Reducing microglial activity in the presence of apolipoprotein E4 (APOE4) has uncovered a mechanism associated with the deposition of misfolded amyloid and tau in a novel mouse model of Alzheimer’s ...

POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue.

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein-;the most important genetic risk factor for ...

Researchers find that a gene linked to Alzheimer's triggers inflammation in healthy brain immune cells, offering new insights ...

New research shows that microglia, which usually clear debris, cause harmful inflammation in the presence of APOE4 protein.

A team of scientists has found that the presence of the APOE4 protein -- the most important genetic risk factor for Alzheimer ...

Lipids Open the Door. Microglial cells treated with unlipidated (top) or lipidated (bottom) ApoE (yellow) along with fluorescently tagged Aβ (green). Lipidated ApoE was more readily internalized and ...