MODEL-AD consortium creates new models of late-onset AD. In LOAD2 mice on a high-fat diet, synapses go haywire even without ...

It has long been known that when red blood cells break down or anemia occurs due to bleeding, the hormone erythropoietin (EPO ...

A research team has discovered a mechanism in which blood stem cells respond to acute, severe anemia, through lipoprotein metabolism modification. It has been known how immediate erythroid precursors ...

Red blood cells are the most abundant cells in the body. It has long been known that when red blood cells break down or anemia occurs due to bleeding, the hormone erythropoietin (EPO) increases, ...

The APOE3 Targeted Replacement model is one line in a set of three APOE knock-in lines created by Nobuyo Maeda, Patrick Sullivan, and colleagues. APOE2 and APOE4 Targeted Replacement mice are also ...

They took mice genetically predisposed to overproduce amyloid and modified them to carry the human APOE gene with the Christchurch mutation. Then, they injected a tiny bit of human tau into the ...

When nighttime light disrupts the body’s natural rhythms, consequences may include a higher risk of Alzheimer’s disease, a ...

Objective To investigate the effects of vaccination against AGE-LDL in atherosclerosis and involved mechanism. Results Compared with Al(OH) 3 or PBS alone, combined immunisation could significantly ...

In this regard, we used the Apolipoprotein E-deficient (ApoE-/-) mouse model, an established model of hyperlipidaemia and atherosclerosis, that does not become obese when subjected to a high-fat diet, ...

“The mice performed better in cognitive and memory ... it will be interesting to see in future stud­ies whether major risk factors, such as APOE and TREM2, similarly modulate the same TRP ...

Here, we aimed to unveil the mechanisms underlying the protective effects of FGF21 on NASH using APOE*3-Leiden.CETP mice, a well-established model for human-like metabolic diseases. Liver-specific ...