FierceBiotech25d
Takeda fronts $46M for 2nd small molecule collab with BridGene
Takeda has returned to BridGene Biosciences for another small-molecule collaboration—this time focused on immunology as well as neurology. BridGene’s pursuit of undruggable targets is enabled ...
C&EN1mon
Single-Molecule Amplification-Free Detection of Nucleic Acid Biomarkers from Body Fluids via an Optical Microfiber with a Nanointerface
Department of Neurology and Stroke Center, The first Affiliated Hospital & Clinical Neuroscience Institute, Key Lab of Basic and Translational Research of Pan-vascular Diseases, Jinan University, ...
C&EN1mon
Computational Methods for Modeling Lipid-Mediated Active Pharmaceutical Ingredient Delivery
Laboratoire de Biologie et Modélisation de la Cellule, CNRS, UMR 5239, Inserm, U1293, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon, France Centre ...
eLife2y
Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism
A second symmetric DNA molecule (39 bp long) was designed with the twofold axis passing through a central base and produced a structure with a symmetric DNA molecule and with the protein and DNA ...
eLife8y
Structural basis for DNA 5´-end resection by RecJ
The resection of DNA strand with a 5´ end at double-strand breaks is an essential step in recombinational DNA repair. RecJ, a member of DHH family proteins, is the only 5´ nuclease involved in the ...