purine pools are increased only twofold. To meet this demand, lymphocytes must use both salvage and de novo synthesis pathways. Thus the inhibition of DHODH by A77 1726 prevents lymphocytes from ...

Scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have made one of the most ...

Nuri Jeong remembers the feeling of surprise she felt during a trip back to South Korea, while visiting her grandmother, ...

Adults with chronic kidney disease and type 2 diabetes had slower kidney function decline with a combination of the ...

Cancer Research Unit and Department of Chemistry, University of Newcastle, Newcastle upon Tyne, NE2 4HH U.K., AstraZeneca Pharmaceuticals, Alderley Park, Cheshire, U.K., Laboratory of Molecular ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec H3A 2K6, Canada, Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West ...

Uric acid can be controlled by eating a balanced diet and limiting consumption of foods high in purines ... it is a normal component of metabolism. Elevated homocysteine is associated with ...

Both aspartate and cysteine are non-essential amino acids, and their altered levels may indicate altered metabolism of these amino acids in Tregs under different culture conditions. Glycolysis was ...