The hydrolysis of ATP releases energy that is used to drive various cellular processes, such as muscle contraction, nerve impulse transmission, and the synthesis of complex molecules. GTP is another ...

Cells sustain their purine levels through two pathways: De novo synthesis builds purines from scratch ... salvage pathway could be an access route for cancer cells to get their nucleotide supply when ...

DNA is fundamental to the biology of all life on Earth, but how many of us actually know what it is or what it's made of?

There is considerable evidence for a role for metabolic dysregulation, including disordered purine nucleotide metabolism, in the pathogenesis of Alzheimer’s disease (AD). Purine nucleotide synthesis ...

This causes different cell types, such as intestinal cells, to have increased susceptibility to MPA by relying more heavily on the de novo synthesis of purine nucleotides. [37] ...