BOTTOM LINE: The Cleveland Guardians, on a three-game home winning streak, host the Baltimore Orioles. Cleveland is 50-50 overall and 24-24 at home. The Guardians have gone 18-10 in games when they hit two or more home runs.

Three batters into the first inning, Jose Ramirez hit his 21st homer and the Guardians delivered a steady stream of offense on the way to a 6-3 win at Progressive Field. How to watch the Guardians: See how to watch Guardians games with this handy game-by-game TV schedule.

The Cleveland Guardians defeated the Baltimore Orioles 6-3 in a competitive Orioles vs Guardians matchup on July 22, 2025, at Progressive Field, as seen in the sports card above. José Ramírez’s first-inning home run set the tone,

The Cleveland Guardians defeat the Baltimore Orioles 6-3, marking their fourth win in five games since the All-Star break.

The Guardians used a left-handed starter and stacked nine lefties and/or switch-hitters in their lineup to beat the Orioles on Tuesday.

Cleveland Guardians fans haven't forgotten about Josh Naylor, but they do feel much better about the trade that sent him to the Arizona Diamondbacks last Dec. 21.

Every time the Orioles knocked on the door in Cleveland tonight, the Guardians answered. It resulted in the Guards taking Game 2 of this four-game series by a final score of 6-3.First half of the game didn’t go so well for us tonight and I thought we hung in there and the at-bats were good and we put up a couple runs as the game went

José Ramírez, Bo Naylor and Kyle Manzardo go deep as the Guardians extend their streak to 11 straight games with a home run.