The Cleveland Guardians defeated the Baltimore Orioles 6-3 in a competitive Orioles vs Guardians matchup on July 22, 2025, at Progressive Field, as seen in the sports card above. José Ramírez’s first-inning home run set the tone,

Angel Martínez had three hits, José Ramírez homered and the Cleveland Guardians defeated the Baltimore Orioles 6-3 Tuesday night for their fourth win in five games since the All-Star break. Kyle Manzardo and Bryan Rocchio each drove in a pair of runs as the Guardians have won 10 of 12 after a 10-game losing streak to get back to .500 at 50-50.

The Guardians used a left-handed starter and stacked nine lefties and/or switch-hitters in their lineup to beat the Orioles on Tuesday.

Three batters into the first inning, Jose Ramirez hit his 21st homer and the Guardians delivered a steady stream of offense on the way to a 6-3 win at Progressive Field. How to watch the Guardians: See how to watch Guardians games with this handy game-by-game TV schedule.

Cleveland Guardians fans haven't forgotten about Josh Naylor, but they do feel much better about the trade that sent him to the Arizona Diamondbacks last Dec. 21.

CLEVELAND — The Guardians face the Baltimore Orioles as Cleveland, for really the first time this season, looks to continue the recent offensive surge. The Guardians are coming off of a 10-5 win on July 21, and they've averaged more than six runs over their last 11 games.

Jose Ramirez hit a three-run homer and Bo Naylor and Kyle Manzardo had solo shots as the Cleveland Guardians beat the visiting Baltimore Orioles 10-5 in their series opener Monday night.